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  • Title: Prostate-specific antigenic domain of human prostate specific antigen identified with monoclonal antibodies.
    Author: Chu TM, Kawinski E, Hibi N, Croghan G, Wiley J, Killian CS, Corral D.
    Journal: J Urol; 1989 Jan; 141(1):152-6. PubMed ID: 2462065.
    Abstract:
    With the use of five murine monoclonal antibodies (1A5, 2A4, 3F1, F5 and 3A12) and an antigen-affinity purified goat polyclonal IgG antibody, the presence of a prostate-specific antigenic domain in human prostate-specific antigen molecule was identified. The results were based upon a series of quantitative competitive inhibition assays of each 125I-labeled monoclonal antibody and polyclonal antibody binding to prostate-specific antigen by unlabeled monoclonal antibodies as inhibitors, and immunohistochemical examination of an extensive panel of human tissue specimens. A cluster of two epitopes that are spatially related or in close topographical proximity and represent a prostate-specific antigenic domain are defined by the monoclonal antibodies 1A5, 2A4, 3F1, and F5, 3A12, respectively.
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