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  • Title: Cholinesterase activities in uterus of normal and fenchlorphos treated blue foxes (Alopex lagopus) during various reproductive states.
    Author: Berge GN, Sterri SH, Søli NE.
    Journal: Acta Vet Scand; 1988; 29(1):117-23. PubMed ID: 2462338.
    Abstract:
    The uterine acetylcholinesterase and total cholinesterase (acetylcholinesterase plus butyrylcholinesterase) activities in normal and fenchlorphos treated blue fox vixens were determined during various reproductive states. AChE and Total-ChE of non-medicated vixens in oestrus were about one half of those in anoestrus. In pregnant uteri (luteal phase) the activities were 25 % and 30% compared to anoestrus. In vixens given 100 mg/kg fenchlorphos for 3 weeks during anoestrus, the remaining activity of AChE in uterus were in average 37%. Pregnant and non-pregnant vixens in the luteal phase medicated prior to mating and during time of implantation, displayed AChE activities which were only moderabely reduced (remaining activities 83% and 72% compared to medicated animals in anoestrus: remaining activity 37%). Plasma ChE-activity increased during pregnancy in the controls while enzyme activity was strongly reduced in animals given 100 mg/kg fenchlorphos daily through the whole pregnancy. It was concluded that the previous reported embryotoxic effect of fenchlorphos in the blue fox did not seem to be directed towards the moderate inhibition of the uterine cholinesterases. Acetylkolinesterase og total kolinesterase (acetylkolinesterase pluss butyrylkolinesterase) aktiviteter i uterus hos normale og fenklorfos-behandlede blårever ble undersøkt under seksualsyklus og drektighet. Resultatene viste at kolinesteraseaktivitetene varierte i de ulike reproduksjonsstadiene. Aktivitetene var høyest i anøstrus og lavest i lutealfasen (drektige dyr). Hos blårevtisper som ble administrert 100 mg/kg fenklorfos daglig i 3 uker av anøstrus, var aktiviteten av AChE i uterus 37%. Tisper, administrert fra 10. dag før parring til 21. dag etter, viste imidlertid både hos drektige og tomme dyr i lutealfasen kun en moderat hemning av AChE sammenlignet med behandlede dyr i anøstrus. Plasma kolinesteraseaktiviteter økte under drektigheten på kontrolldyrene, mens enzymaktivitetene falt tydelig hos dyr gitt 100 mg fenklorfos/kg daglig gjennom hele drektighetsperioden. Det konkluderes med at det er liten sannsynlighet for at den tidligere rapporterte embryotoksiske effekten av fenklorfos kan settes i forbindelse med den moderate hemningen av kolinesterasene i uterus.
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