These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The in vitro activation of cyclic AMP production by either forskolin or isoproterenol in the Syrian hamster pineal during the day is not accompanied by an increase in melatonin production.
    Author: Santana C, Guerrero JM, Reiter RJ, Troiani ME.
    Journal: Biochem Biophys Res Commun; 1988 Dec 30; 157(3):930-6. PubMed ID: 2462873.
    Abstract:
    The role of cyclic AMP in the regulation of melatonin production was investigated in cultured Syrian hamster pineal glands. Forskolin markedly increased cyclic AMP production in pineal glands collected either late in the light period or in the dark period. The effect of forskolin was synergistically enhanced by 3-isobutylmethylxanthine, a phosphodiesterase inhibitor; however, increase in cyclic AMP after isoproterenol was only apparent in the presence of 3-isobutylmethylxanthine. Since beta-adrenergic agonists are able to stimulate melatonin production late in the dark period only, these data suggest that, in the hamster pineal gland, there may be intracellular mechanisms in addition to a cyclic AMP increase required for induction of melatonin production by beta-adrenergic agonists.
    [Abstract] [Full Text] [Related] [New Search]