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  • Title: LINE(1)s of evidence in HBV-driven liver cancer.
    Author: Heikenwalder M, Protzer U.
    Journal: Cell Host Microbe; 2014 Mar 12; 15(3):249-50. PubMed ID: 24629329.
    Abstract:
    Hepatitis B virus (HBV) integration in hepatocellular carcinoma (HCC) is a poorly understood event. In a recent Cancer Cell paper, Lau et al. (2014) describe a HBV-human fusion transcript (HBx-LINE1) that functions as a lncRNA, influences the epithelial-mesenchymal transition, and correlates with reduced patient survival and tumor formation in mice.
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