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  • Title: [Monoclonal antibodies against the beta subunit of human chorionic gonadotropin].
    Author: Fidler R, Sokolov AV, Verbitskiĭ MSh, Papazov IP.
    Journal: Biull Eksp Biol Med; 1988 Dec; 106(12):693-5. PubMed ID: 2462933.
    Abstract:
    The aim of investigation was creation of hybridomas, which produce monoclonal antibodies to the beta-subunit of human chorionic gonadotropin (beta-hCG), characterization of monoclonal antibodies, which necessary for hCG immunoassay in biological fluids, as an immunological methods of detection of early stage of pregnancy and choriocarcinoma. 4 hybridomas, producing monoclonal antibodies to-hCG of IgG1 isotype, were created. On the base of monoclonal antibodies, which produced by D2 hybridoma cell line, test-systems for RIA of hCG in blood serum and urine were elaborated. These test-systems can be used in medical practice for diagnosis of early stages of pregnancy and choriocarcinoma.
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