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  • Title: Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents.
    Author: Mishra A, Batchu H, Srivastava K, Singh P, Shukla PK, Batra S.
    Journal: Bioorg Med Chem Lett; 2014 Apr 01; 24(7):1719-23. PubMed ID: 24630564.
    Abstract:
    Synthesis and bioevaluation of new diaryl ether hybridized quinoline derivatives as antiplasmodial, antibacterial and antifungal agents is reported. It was encouraging to discover that several compounds displayed 2-3 folds better efficacy than chloroquine in chloroquine-resistant K1 strain of Plasmodium falciparum. Further, a few members of the library displayed good antibacterial efficacy against gram positive strains of bacteria but none of the compounds displayed any significant antifungal activity.
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