These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Design, synthesis & evaluation of condensed 2H-4-arylaminopyrimidines as novel antifungal agents.
    Author: Jain KS, Khedkar VM, Arya N, Rane PV, Chaskar PK, Coutinho EC.
    Journal: Eur J Med Chem; 2014 Apr 22; 77():166-75. PubMed ID: 24631896.
    Abstract:
    A small, focussed library of condensed 2H-4-arylaminopyrimidines, with 3-diversity points, based on an initial design by molecular docking study of this scaffold at the active site of the fungal enzyme of cytochrome P450 family, lanosterol 14α-demethylase (CYP51) was synthesized through a one-pot green chemical synthetic protocol. The screening of the synthesised compounds for antifungal activity against Candida albicans, Aspergillus fumigatus &Aspergillus niger revealed activity in many of the compounds as comparable to that of fluconazole. Based on the antifungal activity and physicochemical property data of these derivatives, a meaningful SAR has been proposed.
    [Abstract] [Full Text] [Related] [New Search]