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  • Title: High versus low vancomycin serum trough regimen for Gram-positive infections: a meta-analysis.
    Author: Meng L, Fang Y, Chen Y, Zhu H, Long R.
    Journal: J Chemother; 2015 Aug; 27(4):213-20. PubMed ID: 24641266.
    Abstract:
    This study aimed to evaluate the impact of high vancomycin serum trough concentrations (≧15 mg/l) on clinical outcomes and nephrotoxicity among adult subjects. We searched MEDLINE, Cochrane Library, and CNKI systematically. A total of 17 studies were included. Meta-analysis found that high trough group showed no significant difference comparing to low trough group in treatment failure [relative risk (RR) 0·91, 95% confidence interval (CI) 0·67-1·24; P = 0·57] and all-cause mortality (RR 1·14, 95% CI 0·81-1·59; P = 0·46). However, the high trough concentrations were associated with lower treatment failure in bacteremia subgroup (RR 0·72, 95% CI 0·59-0·88; P = 0·001). High trough concentrations were associated with an increased risk of vancomycin-induced nephrotoxicity (RR 2·06, 95% CI 1·52-2·79; P<0·00001). Our meta-analysis indicates that high trough concentrations were not significantly superior to low trough concentrations in lowering treatment failure and mortality. Moreover, high trough concentrations significantly increased the risk of nephrotoxicity.
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