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  • Title: Synthesis and biological activity of Citridone A and its derivatives.
    Author: Fukuda T, Shimoyama K, Nagamitsu T, Tomoda H.
    Journal: J Antibiot (Tokyo); 2014 Jun; 67(6):445-50. PubMed ID: 24643052.
    Abstract:
    Citridone A (1), originally isolated as a potentiator of antifungal miconazole activity from a fungal culture broth, has a phenyl-R-furopyridone structure. Because of its unique ring structure, 11 derivatives were chemically synthesized and their biological activity was evaluated. Derivatives 17, 20 and 21 potentiated miconazole activity against Candida albicans. Furthermore, 1, 14, 20 and 21 were found to inhibit yellow pigment production in methicillin-resistant Staphylococcus aureus.
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