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  • Title: Cholesterol-dependent gramicidin A channel inactivation in red blood cell membranes and lipid bilayer membranes.
    Author: Schagina LV, Blaskó K, Grinfeldt AE, Korchev YE, Lev AA.
    Journal: Biochim Biophys Acta; 1989 Jan 16; 978(1):145-50. PubMed ID: 2464373.
    Abstract:
    The exchange diffusions of tracer cations (22Na+, 86Rb+) are studied on gramicidin-A-treated red blood cell (RBC) membranes. A time-dependent decrease in cation permeability has been observed and has been considered to be the result of a channel inactivation process. The channel inactivation appears at 20 and 30 degrees C but not at a temperature as low as 6 degrees C. The gramicidin A channel inactivation can be monitored by a conductivity decay of molecular lipid membranes (BLM) prepared either from cholesterol or from a mixture of cholesterol and phospholipids but not of pure phosphatidylethanolamine. The role of cholesterol in the channel inactivation is discussed.
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