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  • Title: Synthesis of thiazolines by copper catalyzed aminobromination of thiohydroximic acids.
    Author: Lemercier BC, Pierce JG.
    Journal: Org Lett; 2014 Apr 04; 16(7):2074-6. PubMed ID: 24645640.
    Abstract:
    A copper catalyzed aminobromination of alkene tethered thiohydroximic acids is described, providing a rapid approach to unnatural thiazoline scaffolds not readily available via existing methods. Moderate to high yields of bromothiazolines are obtained with alkyl- and aryl-substituted thiohydroximic acid building blocks containing mono-, di-, and trisubstituted alkenes. The reaction provides high levels of 5-exo selectivity, and terminally monosubstituted alkenes result in predominant syn-diastereoselectivity.
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