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  • Title: Transforming growth factor-beta inhibits cellular adenylate cyclase activity in cultured human arterial endothelial cells.
    Author: Mioh H, Chen JK.
    Journal: In Vitro Cell Dev Biol; 1989 Jan; 25(1):101-4. PubMed ID: 2464571.
    Abstract:
    Stimulation of human arterial endothelial cells with heparin-binding growth factor-1 (HBGF-1) resulted in a 40% to 60% increase in the cellular adenylate cyclase activity and intracellular cAMP content. The stimulatory effect of HBGF-1 was effectively suppressed by pretreating the cells with transforming growth factor-beta (TGF-beta), an endothelial cell growth inhibitor. The inhibition of the adenylate cyclase activity precedes growth inhibition by at least 24 h. The half maximal inhibitory dose was calculated to be 0.2 ng/ml for the inhibition of both cyclase activity and cell growth. The possible role of the adenylate cyclase suppression in growth inhibition by TGF-beta is discussed.
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