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  • Title: [Alpha-fetoprotein and trisomy 21].
    Author: Guibaud S, Boisson C, Simplot A, Thoulon JM, Favier JP, Guibaud P, Robert JM.
    Journal: J Genet Hum; 1988 Aug; 36(4):347-51. PubMed ID: 2464665.
    Abstract:
    In 31 affected pregnancies with Down syndrome, the median maternal serum alpha-fetoprotein value was lower than normal, 0.76 MoM, and median amniotic fluid value was quite normal, 0.98 MoM. Selecting an arbitrary cutoff-point of 0.5 MoM, 4.1 percent of normal gestations show values less than 0.5 MoM. Authors discuss problems about screening for fetal Down's syndrome by measuring maternal serum AFP levels.
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