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  • Title: Phenotype and functional properties of Vicia villosa agglutinin (VVA) binding T cells in patients with Crohn's disease: detection of contrasuppressor activity in patients lacking extra-intestinal manifestations, abscesses and fistulas.
    Author: Raedler A, Lenz HJ, Sandgren K, de Weerth A, Enversen S, Schreiber S, Thiele HG, Greten H.
    Journal: Clin Exp Immunol; 1988 Nov; 74(2):264-9. PubMed ID: 2465109.
    Abstract:
    Patients with active Crohn's disease (CD) have significantly increased numbers of T cells binding the Vicia villosa agglutinin (VVA). In patients with CD these VVA+ T cells express either the CD4 or the CD8 determinants, while in normal controls the majority of VVA+ T cells are CD8+. VVA+ T cells are significantly decreased in number in the inflamed mucosa as compared to normal controls. However, in only a subgroup of the patients do the VVA+ T cells show contrasuppressor activity with respect to the IgA and total Ig secretion upon co-cultivation with autologous B cells. Regression analysis revealed that in all data presented, contrasuppression activity correlates significantly with the absence of extra-intestinal symptoms, abscesses and fistulas.
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