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  • Title: Antiresorptive drug-related osteonecrosis of the jaw.
    Author: Uyanne J, Calhoun CC, Le AD.
    Journal: Dent Clin North Am; 2014 Apr; 58(2):369-84. PubMed ID: 24655528.
    Abstract:
    Nitrogen-containing and non-nitrogen-containing bisphosphonates have been implicated in the development of osteonecrosis of the jaw (ONJ), a condition termed bisphosphonate-related OHJ. Other antiresorptive drugs have been implicated in the development of OHJ, hence the new term antiresorptive drug-related ONJ. The underlying pathogenesis remains unclear, and no definite diagnosis or cure has been established for this debilitating condition. This article reviews some of the most common antiresorptive drugs with their associated risks of ONJ and the current understanding of the pathogenesis ONJ, and summarizes current clinical guidelines.
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