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  • Title: Parathyroid hormone inhibition of Na+/phosphate cotransport in OK cells: generation of second messengers in the regulatory cascade.
    Author: Quamme G, Pfeilschifter J, Murer H.
    Journal: Biochem Biophys Res Commun; 1989 Feb 15; 158(3):951-7. PubMed ID: 2465766.
    Abstract:
    Dose-dependent inhibition of Na/phosphate cotransport by parathyroid hormone (PTH) was correlated with the generation of hormone-mediated second messengers, cAMP, 1,2-diacylglycerol and inositol 1,4,5 trisphosphate in an established epithelial cell line (opossum kidney (OK) cells). PTH results in a dose-dependent decline in Na/phosphate cotransport with a half-maximal response at about 10(-11) M. This hormone concentration is commensurate with the levels required to increase 1,2-diacylglycerol and inositol 1,4,5-trisphosphate concentrations by about half maximal but not with those needed for cAMP generation (10(-9) to 10(-8) M PTH). Accordingly, activation of phospholipase C may be physiologically more important than stimulation of adenylate cyclase at normal PTH levels.
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