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  • Title: Pinacidil actions on ion channels in vascular muscle.
    Author: Hermsmeyer RK.
    Journal: J Cardiovasc Pharmacol; 1988; 12 Suppl 2():S17-22. PubMed ID: 2466175.
    Abstract:
    Electrophysiological and mechanical recordings from isolated single vascular muscle cells and isolated segments of caudal artery showed that pinacidil caused vascular muscle relaxation and hyperpolarization which originates from increased K+ conductance. Voltage-clamp recordings of current flow through single K+ channels strongly suggest that pinacidil increases the specific type of K+ conductance associated with the Ca2+-dependent "big" K+ channel (unit conductance of 200 pS in symmetrical K+ solutions). The increased opening of K+ channels appears certain to be an important cellular mechanism to vasodilation by pinacidil.
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