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  • Title: [Immunohistochemical and radiologic study of the accumulation of antibodies to the beta-1-MA antigen in human tumors transplanted into athymic mice].
    Author: Pugachev KK, Aleksandr SK, Fidler LM, Revazova ES, Shimbireva IB.
    Journal: Eksp Onkol; 1989; 11(1):50-3. PubMed ID: 2466632.
    Abstract:
    Human tumours and tissues of nude mice were studied immunohistochemically using rabbit antibody to the beta-1-MA. Specific reaction was observed in colonic carcinomas, beta-1-MA was not found in other tumours. The specific reaction was found in intestinal epithelium of nude mice, and was absent in other tissues. 131I-labelled antibody to the beta-1-MA was intravenously administered to tumour-bearing nude mice. Specifically connected antibodies were revealed by immunohistochemical method in colonic carcinomas only. Radioimmunological investigation has shown accumulation of 131I-labelled antibodies to the beta-1-MA in colonic carcinomas.
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