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  • Title: A double-blind crossover comparison of amlodipine and placebo added to captopril in moderate to severe hypertension.
    Author: Maclean D, Mitchell ET, Wilcox RG, Walker P, Tyler HM.
    Journal: J Cardiovasc Pharmacol; 1988; 12 Suppl 7():S85-8. PubMed ID: 2467137.
    Abstract:
    Amlodipine 10 mg once daily added to captopril 25 mg twice daily for 4 weeks in patients with moderate to severe hypertension significantly improved blood pressure control (by -18/-12 and -20/-12 mm Hg for supine and standing systolic/diastolic pressures respectively, p less than 0.001). Few side effects related to amlodipine were noted and none was serious.
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