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  • Title: Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.
    Author: Ishikawa F, Miyazono K, Hellman U, Drexler H, Wernstedt C, Hagiwara K, Usuki K, Takaku F, Risau W, Heldin CH.
    Journal: Nature; 1989 Apr 13; 338(6216):557-62. PubMed ID: 2467210.
    Abstract:
    Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo.
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