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  • Title: Immunohistological study of Crooke's cells.
    Author: Uei Y.
    Journal: Pathol Res Pract; 1988 Sep; 183(5):636-7. PubMed ID: 2467271.
    Abstract:
    By immunohistochemical methods, 28 postmortem pituitary glands with unequivocal Crooke's hyaline change were examined to identify the hyaline material. Crooke's hyaline was positive for 55-57 kilodalton (KD) cytokeratin (CK) but negative for 68 KD CK, vimentin, desmin, neurofilament and glial fibrillary acidic protein. Involucrin, a new marker for keratinocyte differentiation, could also not be demonstrated. It was concluded that Crooke's hyaline was an abnormally accumulated CK which is a normal constituent of the ACTH cell.
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