These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Murine granulocyte colony-stimulating factor: actions on normal and leukemic cells.
    Author: Nicola NA.
    Journal: Behring Inst Mitt; 1988 Aug; (83):207-15. PubMed ID: 2467648.
    Abstract:
    Granulocyte colony-stimulating factor (G-CSF) is a strongly conserved glycoprotein which induces the survival, proliferation and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. The actions of G-CSF are mediated through a small number of specific cellular receptors which are induced to internalize and accumulate within the cell after binding of G-CSF at 37 degrees C. G-CSF receptors can be lost from the cell surface not only by binding G-CSF, but indirectly by other factors including GM-CSF, Multi-CSF, bacterial lipopolysaccharides, chemotactic peptides and phorbol esters, depending on cell type. Possible relationships of these processes to the mechanism of action of G-CSF are discussed.
    [Abstract] [Full Text] [Related] [New Search]