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  • Title: Endometrial intraepithelial neoplasia.
    Author: Owings RA, Quick CM.
    Journal: Arch Pathol Lab Med; 2014 Apr; 138(4):484-91. PubMed ID: 24678678.
    Abstract:
    CONTEXT: Developed in conjunction with molecular and progression data, the sequence classification schema for endometrial intraepithelial neoplasia (EIN)/benign hyperplasia (BH) provides an easy to adopt and reproducible method for classification of endometrial biopsies. OBJECTIVE: To review current data supporting the use of BH/EIN to classify endometrial biopsies, and to discuss the hormone-driven endometrial sequence from anovulation/disordered proliferative endometrium through BH and EIN and their diagnostic difficulty. DATA SOURCES: A comprehensive review of EIN literature based on literature indexed by PubMed (National Library of Medicine) and Google Scholar. CONCLUSIONS: The BH/EIN schema is gaining wider acceptance among pathologist and clinicians. The research leading to the EIN criteria is based on molecular and progression data. The BH/EIN schema has better reproducibility among pathologists, is intuitively easy to use, and requires understanding of endometrial physiology and neoplasia.
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