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  • Title: Structural elucidation and synthesis of vialinin C, a new inhibitor of TNF-α production.
    Author: Ye YQ, Negishi C, Hongo Y, Koshino H, Onose J, Abe N, Takahashi S.
    Journal: Bioorg Med Chem; 2014 Apr 15; 22(8):2442-6. PubMed ID: 24679673.
    Abstract:
    A new inhibitor of TNF-α production (IC50=0.89 μM) named vialinin C (1) was isolated from dry fruiting bodies of an edible Chinese mushroom, Thelephora vialis. The structure of 1 was determined by high-resolution MS, NMR spectroscopic analysis, and confirmed by synthesis. Synthesis of ganbajunin B (5) obtained from the same origin was also described.
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