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  • Title: Contrasting time course of catecholamine accumulation and of spontaneous discharge in experimental neuromas in the rat.
    Author: Goldstein RS, Raber P, Govrin-Lippmann R, Devor M.
    Journal: Neurosci Lett; 1988 Nov 22; 94(1-2):58-63. PubMed ID: 2468116.
    Abstract:
    Catecholamine-containing sympathetic axons in rat sciatic nerve-end neuromas were visualized histochemically. Within a few hours of ligating and sectioning the nerve, axons began to accumulate catecholamine histofluorescence. Density of labelled fibers peaked 2-5 days postoperative, then declined rapidly so that little or no label was observed beyond 12 days. Sympathectomy eliminated staining; neonatal treatment with capsaicin had no effect. Accumulation and dissipation of histofluorescence preceded the rise and fall of electrical hyperexcitability in neuromas by several days respectively.
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