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  • Title: Ectopic production of the beta-subunit of human chorionic gonadotropin in osteosarcoma.
    Author: Ordóñez NG, Ayala AG, Raymond AK, Plager C, Benjamin RS, Samaan NA.
    Journal: Arch Pathol Lab Med; 1989 Apr; 113(4):416-9. PubMed ID: 2468324.
    Abstract:
    Production of human chorionic gonadotropin by sarcomas is an uncommon phenomenon that has rarely been documented. A case of a 26-year-old woman with osteosarcoma of the left fibula and high levels of serum beta-human chorionic gonadotropin (beta-HCG) is described. Immunoperoxidase staining showed numerous tumor cells reacting with the beta-HCG antibody. Immunohistochemical studies performed on ten additional osteosarcomas demonstrated another case in which some tumor cells presented immunoreactivity for beta-HCG. These results indicate that beta-HCG may be used as a marker of persistent or recurrent disease in those uncommon cases of osteosarcoma in which serum levels of beta-HCG are elevated at the onset of treatment.
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