These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19.
    Author: Riegman PH, Vlietstra RJ, Klaassen P, van der Korput JA, Geurts van Kessel A, Romijn JC, Trapman J.
    Journal: FEBS Lett; 1989 Apr 10; 247(1):123-6. PubMed ID: 2468530.
    Abstract:
    Using a prostate-specific antigen cDNA as a hybridization probe, clones containing the kallikrein genes encoding prostate-specific antigen, human glandular kallikrein-1 and pancreas/kidney kallikrein were isolated from a human genomic library. Clones containing the prostate-specific antigen gene and the human glandular kallikrein-1 gene overlap and span a region of about 36 kb. The two genes are aligned in a head to tail orientation at a mutual distance of 12 kb. Southern blot analysis of DNA from a panel of human-hamster hybrid cells with specific probes revealed the genes to be situated on chromosome 19. Assuming that the pancreas/kidney kallikrein gene is located in the same cluster, the distance to the prostate-specific antigen gene and the human glandular kallikrein gene must be at least 15 kb.
    [Abstract] [Full Text] [Related] [New Search]