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  • Title: Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.
    Author: Mitchell EB, McCall JW, Theodore Chester S, Larsen D.
    Journal: Vet Parasitol; 2014 Apr 02; 201(3-4):223-5. PubMed ID: 24685321.
    Abstract:
    Efficacy of afoxolaner, a novel isoxazoline insecticide/acaricide, against Ixodes scapularis was evaluated in a laboratory study. One day prior to treatment, beagle dogs (n=16) were infested with 50 unfed wild adult ticks. Repeat infestations were performed weekly for four additional weeks. The number of live ticks remaining on each dog was determined 48 h after treatment and after each subsequent infestation. A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30.
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