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  • Title: Cytotoxic T lymphocyte recognition of secreted HLA class I molecules.
    Author: Kahn-Perles B, Barra C, Jehan J, Fourel D, Barad M, Maryanski JL, Lemonnier FA.
    Journal: J Immunol; 1989 May 01; 142(9):3021-5. PubMed ID: 2468709.
    Abstract:
    The cytolytic responses of DBA/2 mice against syngeneic transfected P815 mastocytoma cells expressing either membrane-associated (HLA-Cw3) or -secreted hybrid (HLA-Cw3 x H-2 Q10b) molecules were compared. In spite of the absence of serologically detectable hybrid molecules on their plasma membrane, cells secreting these molecules elicited a CTL response similar to that of cells expressing the membrane associated HLA-Cw3 molecules, in terms of both MHC-restriction and peptide specificity. Together with the observation that syngeneic mice were capable of rejecting the injected secreting cells, these results imply that secreted HLA class I molecules can function as minor histocompatibility Ag and suggest that processing of both the membrane-bound and the -secreted forms of a protein may follow common or overlapping pathways.
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