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  • Title: [Bactericidal action of lomefloxacin a new pyridonecarboxylic acid derivative].
    Author: Koikeda S, Okabe H, Shibata H, Hase T, Nakanishi N, Okezaki E, Kato H, Masamune Y.
    Journal: Jpn J Antibiot; 1989 Jan; 42(1):193-9. PubMed ID: 2468799.
    Abstract:
    Lomefloxacin (NY-198) [(+/-)-1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo -3- quinolinecarboxylic acid hydrochloride] strongly inhibited the growths of not only Gram-negative Escherichia coli but Gram-positive Staphylococcus aureus. In vivo and in vitro experiments showed deoxyribonucleic acid (DNA) synthesis was specifically inhibited by this drug in E. coli.
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