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  • Title: Effect of insulin on the growth of a human hepatoma cell line PLC/PRF/5: a possible role of insulin receptor.
    Author: Motoo Y, Kobayashi K, Hattori N.
    Journal: Tohoku J Exp Med; 1988 Dec; 156(4):351-7. PubMed ID: 2469133.
    Abstract:
    Insulin produced increases in cell number, DNA synthesis and alpha-fetoprotein secretion of a human hepatoma cell line PLC/PRF/5. The insulin-treated cells showed a decrease in binding of 125I-insulin. The decreased binding was due to the decreased numbers as well as the low affinity constant of insulin receptor. These data suggest that insulin is a growth factor for the human hepatoma cells and that insulin receptor plays a role in the growth-promoting effect of insulin.
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