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  • Title: Calcium channel regulation by calcineurin, a Ca2+-activated phosphatase in mammalian brain.
    Author: Armstrong DL.
    Journal: Trends Neurosci; 1989 Mar; 12(3):117-22. PubMed ID: 2469218.
    Abstract:
    The enzymatic addition or removal of phosphate esters on serine and threonine hydroxyls alters the activity of many proteins that contribute to the characteristic structure and function of nerve cells. Recently, calcineurin, a major calmodulin-binding protein in mammalian brain, has been purified and identified as a Ca2+-activated protein phosphatase. Preliminary experiments suggest that calcineurin may limit Ca2+ influx through dihydropyridine-sensitive Ca2+ channels in the plasma membrane by dephosphorylating the channel, or a closely associated protein, and inactivating it.
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