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  • Title: New steroids with a rearranged skeleton as (h)P300 inhibitors from the sponge Theonella swinhoei.
    Author: Gong J, Sun P, Jiang N, Riccio R, Lauro G, Bifulco G, Li TJ, Gerwick WH, Zhang W.
    Journal: Org Lett; 2014 Apr 18; 16(8):2224-7. PubMed ID: 24694058.
    Abstract:
    Swinhoeisterols A (1) and B (2), two novel sterols with an unprecedented 6/6/5/7 ring system, were isolated from the sponge Theonella swinhoei. The structures and absolute configurations were elucidated by spectroscopic analysis, X-ray single-crystal diffraction, modified Mosher's method, and TDDFT/ECD calculations. The cytotoxicity of these compounds toward A549 and MG-63 cells encourages studies on their potential target using an inverse virtual screening approach. The predicted inhibitor of h(p300) was corroborated by an in vitro biological test.
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