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  • Title: [Electron microscopic-radioautographic study of RNA synthesis in the epithelial cells of the kidney urinary tubules of white rats in corrosive sublimate poisoning].
    Author: Andreev VP, Pal'tsyn AA.
    Journal: Biull Eksp Biol Med; 1989 Mar; 107(3):357-60. PubMed ID: 2469489.
    Abstract:
    Radioautographic study of ultrathin selections of proximal white rat renal canals labeled with 3H-uridine revealed diffuse transition of peripheral and paranuclear heterochromatin to be observed in nuclei of undamaged epithelia cells and those affected by partial necrosis in case of sublimate nephrosis. Nucleus degranulation as well as decrease in its size accompanied by inhibition of RNA synthesis is also observed. Nucleus reparation being observed 48 hours after subcutaneous injection of 0.4/0.1 kg corrosive sublimate in some cells and characterized by the appearance of granular component as well as the increase of nucleolar vacuole count is usually revealed in case of decondensation form of peripheral and paranuclear chromatin in the enlarged nuclei.
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