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  • Title: Age-related effects of antihypertensive therapy with alpha-blockers.
    Author: Stokes GS.
    Journal: J Cardiovasc Pharmacol; 1988; 12 Suppl 8():S109-15. PubMed ID: 2469891.
    Abstract:
    Currently, the most important alpha-blockers used in treating hypertension are prazosin and its long-acting congeners, doxazosin and terazosin. Although there are minor age-related changes in the pharmacokinetics of these compounds, they result in no appreciable alteration in dose requirements. Overall, published evidence does not indicate any loss of responsiveness to alpha-blockade in the elderly. Despite the potential risks of first-dose hypotension and of postural hypotension, long-acting alpha-blockers may warrant further consideration as possible first-line therapy in elderly hypertensive patients. These agents allow the simplicity of once-daily dosing, and their cardiac and metabolic effects offer potential advantages.
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