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  • Title: [Characteristics of the silver-stained nucleoli in blast elements of various diameters from patients with acute leukemia].
    Author: Mamaev NN, Martinez H, Morozova EO, Ivanova NA.
    Journal: Tsitologiia; 1988 Dec; 30(12):1478-82. PubMed ID: 2470179.
    Abstract:
    Using silver staining, a study was made of the activity of ribosomal cistrons (RC) in proliferating and non-proliferating subpopulations of bone marrow and peripheral blood blasts, taken from 33 patients with acute non-lymphoblastic leukemia and from 17 patients with acute lymphoblastic leukemia. All the blasts including non-proliferating ones were revealed to synthesize ribosomal RNA (rRNA). The RC activity of large blasts was higher than that of small ones. A significant difference (P less than 0.01) in RC activity between lymphoid and non-lymphoid blasts was found. The relation between nucleolar organizer activity of blasts and their proliferating potentials is discussed, in addition to a possibility for practical use of the above mentioned data.
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