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  • Title: Desensitisation of human platelets against stimulation by thromboxane mimics--reduction in receptor capacity and loss of functional response.
    Author: Thierauch KH, Gabriel D, Prior G, Schillinger E.
    Journal: Biomed Biochim Acta; 1988; 47(10-11):S75-8. PubMed ID: 2470362.
    Abstract:
    Number and affinity of thromboxane A2/PGH2 receptors on gel-filtered human platelets was determined using the receptor antagonist 3H-SQ 29548 as a tracer compound. Preincubation of platelet rich plasma (PRP) with U 46619 reduced receptor number to 31% of control platelets without affecting the affinity (2 x 10(-9) mol/l). Pretreated platelets lost their reactivity to stimulation by U 46619 but not to thrombin within 3 h. It is concluded that preincubation of platelets leads to a homologeous platelet desensitisation and down regulation of thromboxane receptors.
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