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  • Title: Effects of substance P (SP) and the N-terminal SP-analogue SP (1-4) on inositol phospholipids in rat adrenal medulla slices.
    Author: Minenko A, Tjulkova E, Oehme P.
    Journal: Biomed Biochim Acta; 1988; 47(9):871-9. PubMed ID: 2470365.
    Abstract:
    We previously demonstrated that SP (1.10(-6) M) stimulates the hydrolysis of inositol phospholipids from adrenal medulla slices of Wistar rats (Biomed. Biochim. Acta 46, 461-467 (1987]. In this study we compared the effects of SP and the N-terminal SP-analogue SP(1-4) on inositol phospholipids and their water-soluble metabolites. The effect of SP (1-4) on 32P incorporation into inositol PL is substantially smaller than that of SP. However, the results obtained with [3H]inositol-prelabelled slices show that both peptides cause a diesteratic hydrolysis of inositol phospholipids. For both peptides a significant decrease in [3H]phosphatidylinositol-4,5-bisphosphate as well as an accumulation of [3H]inositol-bisphosphates were observed. There is a significant difference between the effects of SP and SP (1-4): SP stimulates the accumulation of glycerophosphorylinositols, whereas SP (1-4) inhibits its production. These effects of both peptides are discussed in the light of their effects on the catecholamine system.
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