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  • Title: Properties of gramicidin A channels in erythrocyte membranes.
    Author: Blaskó K, Schagina LV, Györgyi S, Rontó G.
    Journal: Biochimie; 1989 Jan; 71(1):99-104. PubMed ID: 2470422.
    Abstract:
    Studies for the cation permeability properties of the gramicidin A channel in erythrocyte membranes are presented. It is shown that gramicidin A interacts with the membrane in a cooperative manner, creating aggregates of the antibiotic molecules in the lipid lattice of the membrane. Cationic channels exist in these aggregates with the following order of selectivity: Rb+ greater than Cs+ greater K+ greater than Na+. The cation permeability of the channels depends on the media surrounding the membrane. This finding has been explained on the basis of Hodgkin-Keynes theory for single-file ion diffusion through extra-narrow pores.
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