These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Purification, characterization and promoting effect on wound healing of an exopolysaccharide from Lachnum YM405.
    Author: He Y, Ye M, Du Z, Wang H, Wu Y, Yang L.
    Journal: Carbohydr Polym; 2014 May 25; 105():169-76. PubMed ID: 24708966.
    Abstract:
    An exopolysaccharide (LEP-2b) with molecular weight of 2.8×10(4)Da was isolated from Lachnum YM405 and purified by DEAE-cellulose 52, Sepharose CL-6B chromatographic column. It consisted of rhamnose (Rha), mannose (Man), glucose (Glc) and galactose (Gal) in a molar ratio of 1.0:5.0:11.5:12.5. Its backbone consisted of →4)-β-d-Manp-(1→, →2)-α-d-Rhap-(1→, →6)-β-d-Glcp-(1→, and →6)-α-d-Galp-(1→, and three types of branches were composed of →6)-α-d-1-OMe-Manf-(2→, →6)-β-d-1-OMe-Manf-(2→, →1)-α-d-Galp-(6→, →1)-β-d-Galp-(6→, and →1)-β-d-Glcp, which were at O-3 of 1,3,6-linked α-d-Manp and O-2, O-3 of the same 1,2,3,6-linked β-d-Glcp in the backbone respectively. LEP-2b ointment significantly accelerated the decrustation of the wounded skin, shortened the healing time and increased the water and hydroxyproline contents of the healed skin. Combined with the results of macroscopic and histological observations, we deemed that LEP-2b could inhibit inflammatory reaction of scalded skin, accelerate tissue repair and re-epithelialization, thereby playing a positive role in promoting wound healing.
    [Abstract] [Full Text] [Related] [New Search]