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  • Title: Renal biopsy: use of biomarkers as a tool for the diagnosis of focal segmental glomerulosclerosis.
    Author: Aparecida da Silva C, Molinar Mauad Cintra M, de Castro Côbo E, Vinícius da Silva M, Bichuette Custódio F, Rosa Miranda Corrêa R, Roberto Castellano L, Antônia dos Reis M, Reis Machado J.
    Journal: Dis Markers; 2014; 2014():192836. PubMed ID: 24719498.
    Abstract:
    Focal segmental glomerulosclerosis (FSGS) is a glomerulopathy associated with nephrotic syndrome and podocyte injury. FSGS occurs both in children and adults and it is considered the main idiopathic nephrotic syndrome nowadays. It is extremely difficult to establish a morphological diagnosis, since some biopsies lack a considerable quantifiable number of sclerotic glomeruli, given their focal aspect and the fact that FSGS occurs in less than half of the glomeruli. Therefore, many biological molecules have been evaluated as potential markers that would enhance the diagnosis of FSGS. Some of these molecules and receptors are associated with the pathogenesis of FSGS and have potential use in diagnosis.
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