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  • Title: CMTM5 exhibits tumor suppressor activity through promoter methylation in oral squamous cell carcinoma.
    Author: Zhang H, Nan X, Li X, Chen Y, Zhang J, Sun L, Han W, Li T.
    Journal: Biochem Biophys Res Commun; 2014 May 02; 447(2):304-10. PubMed ID: 24721428.
    Abstract:
    Oral squamous cell carcinoma (OSCC) is one of the most common types of malignancies in the head and neck region. CKLF-like MARVEL transmembrane domain-containing member 5 (CMTM5) has been recently implicated as a tumor suppressor gene in several cancer types. Herein, we examined the expression and function of CMTM5 in oral squamous cell carcinoma. CMTM5 was down-regulated in oral squamous cell lines and tumor samples from patients with promoter methylation. Treatment with the demethylating agent 5-aza-2'-deoxycytidine restored CMTM5 expression. In the OSCC cell lines CAL27 and GNM, the ectopic expression of CMTM5-v1 strongly inhibited cell proliferation and migration and induced apoptosis. In addition, CMTM5-v1 inhibited tumor formation in vivo. Therefore, CMTM5 might act as a putative tumor suppressor gene through promoter methylation in oral squamous cell carcinoma.
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