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  • Title: Antimalarial diterpene alkaloids from the seeds of Caesalpinia minax.
    Author: Ma G, Sun Z, Sun Z, Yuan J, Wei H, Yang J, Wu H, Xu X.
    Journal: Fitoterapia; 2014 Jun; 95():234-9. PubMed ID: 24727083.
    Abstract:
    Two new diterpene alkaloids, caesalminines A (1) and B (2), possessing a tetracyclic cassane-type furanoditerpenoid skeleton with γ-lactam ring, were isolated from the seeds of Caesalpinia minax. Their structures were determined by different spectroscopic methods and ECD calculation. The plausible biosynthetic pathway of caesalminines A and B was proposed. The anti-malarial activity of compounds 1 and 2 is presented with IC50 values of 0.42 and 0.79 μM, respectively.
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