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  • Title: Synthesis of 6-cinnamoyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and their effects on A549 lung cancer cell growth.
    Author: Zhou XW, Ma HL, Zhang X, Jing SY, Miao JY, Zhao BX.
    Journal: Eur J Med Chem; 2014 May 22; 79():95-101. PubMed ID: 24727462.
    Abstract:
    A series of novel 6-cinnamoyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives was synthesized. The structures of compounds were characterized by (1)H NMR, IR, and MS. Moreover, representative crystal structure was determined by X-ray diffraction analysis. The preliminary biological evaluation of all these compounds showed that compounds 3a-3d would suppress the growth of A549 lung cells effectively by inducing autophagy and cell cycle arrest.
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