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  • Title: Quantification of cerebral perfusion using dynamic quantitative susceptibility mapping.
    Author: Xu B, Spincemaille P, Liu T, Prince MR, Dutruel S, Gupta A, Thimmappa ND, Wang Y.
    Journal: Magn Reson Med; 2015 Apr; 73(4):1540-8. PubMed ID: 24733457.
    Abstract:
    PURPOSE: The purpose of this study is to develop a dynamic quantitative susceptibility mapping (QSM) technique with sufficient temporal resolution to map contrast agent concentration in cerebral perfusion imaging. METHODS: The dynamic QSM used a multiecho three-dimensional (3D) spoiled gradient echo golden angle interleaved spiral sequence during contrast bolus injection. Four-dimensional (4D) space-time resolved magnetic field reconstruction was performed using the temporal resolution acceleration with constrained evolution reconstruction method. Deconvolution of the gadolinium-induced field was performed at each time point with the morphology enabled dipole inversion method to generate a 4D gadolinium concentration map, from which three-dimensional spatial distributions of cerebral blood volume and cerebral blood flow were computed. RESULTS: Initial in vivo brain imaging demonstrated the feasibility of using dynamic QSM for generating quantitative 4D contrast agent maps and imaging three-dimensional perfusion. The cerebral blood flow obtained with dynamic QSM agreed with that obtained using arterial spin labeling. CONCLUSION: Dynamic QSM can be used to perform 4D mapping of contrast agent concentration in contrast-enhanced magnetic resonance imaging. The perfusion parameters derived from this 4D contrast agent concentration map were in good agreement with those obtained using arterial spin labeling.
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