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  • Title: Human chorionic gonadotropin and free subunits' serum levels in patients with partial and complete hydatidiform moles.
    Author: Berkowitz R, Ozturk M, Goldstein D, Bernstein M, Hill L, Wands JR.
    Journal: Obstet Gynecol; 1989 Aug; 74(2):212-6. PubMed ID: 2473429.
    Abstract:
    Serum levels of hCG and its free subunits were measured in patients with partial and complete hydatidiform moles and in women with normal 10-week pregnancies. whereas complete moles had higher levels of percent-free beta-hCG than partial moles (2.4 versus 1.0; P less than or equal to .005), partial moles had higher levels of percent-free alpha-hCG than complete moles (0.85 versus 0.17; P less than or equal to .005). Normal 10-week pregnancies had lower levels of both percent-free beta-hCG and percent-free alpha-hCG than partial moles (0.40 versus 1.0, P less than or equal to .005 and 0.27 versus 0.85, P less than or equal to .005, respectively). Percent-free beta-hCG and beta-hCG levels did not distinguish which patients with complete mole were more likely to develop persistent post-molar tumor. The trophoblastic cells in complete and partial moles differ significantly in the manner in which they secrete the free subunits of hCG.
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