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  • Title: Case report: cytokine and CD4+ T-cell profiles of monozygotic twins with autism and divergent comorbidities and drug treatment.
    Author: Magid-Bernstein J, Mahajan K, Lincoln J, Ming X, Rohowsky-Kochan C.
    Journal: J Child Neurol; 2015 Mar; 30(3):386-90. PubMed ID: 24736120.
    Abstract:
    Autism spectrum disorders are neurodevelopmental disorders that are thought to be caused by a gene-by-environment interaction and in which various immune alterations are reported. We investigate CD4(+) T-cell cytokine profiles and subpopulations in 19-year-old monozygotic twins with autism and different comorbidities. CD4(+) T cells from the twin with epilepsy produce more interferon-gamma, less interleukin-17, and have an increased interferon-γ/interleukin-4 ratio. CD4(+) T cells from the twin with multiple sclerosis exhibit a cytokine profile similar to an age and gender-matched control and a higher percentage of T regulatory (Treg) cells. The twins' mother's T cells produce very high levels of both interleukin-17 and interferon-γ. Cytokine and CD4(+) T-cell abnormalities in the twins could contribute to or be a result of the manifestation of their divergent comorbidities. A proinflammatory, autoimmune-polarized cytokine profile is observed in this unique family with autism.
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