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  • Title: Studies of the mechanism of desensitization of anti-IgE-mediated histamine release from human basophils.
    Author: Andersson RG, Bartonek M, Lindström E, Lindström IM, Toll JB.
    Journal: Agents Actions; 1989 Apr; 27(1-2):25-8. PubMed ID: 2473625.
    Abstract:
    Human basophils became hyporesponsive to anti-IgE when exposed to this agent in the absence of Ca2+ for more than 10 min. The desensitization process proceeded in parallel to the releasing-process. The mechanism of desensitization seems to involve a very early step in the release-reaction, since the response to phospholipase A2 and diolein, agents involved in the release-reaction, was not affected by the desensitization.
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