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  • Title: Beta-adrenoceptor blocking drugs and calcium transport in isolated rat mast cells.
    Author: Drábiková K, Pecivová J, Nosál R.
    Journal: Agents Actions; 1989 Apr; 27(1-2):33-5. PubMed ID: 2473626.
    Abstract:
    The beta-adrenoceptor blocking (BAB) drugs exaprolol (EXA), metipranolol (MET) and propranolol (PRO) inhibited histamine liberation and degranulation from isolated rat mast cells stimulated with the calcium ionophore A23187. MET was the most and EXA the least active. Atenolol (ATE) had no effect. Inhibition by BAB drugs of secretion induced with A23187 was not accompanied by any change in 45Ca uptake. On the other hand, EXA, MET and PRO significantly decreased 45Ca uptake by mast cells stimulated with 48/80. The effect of BAB drugs on inhibition of A23187-induced secretion from isolated mast cells was dependent on the lipid solubility of the studied drugs.
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