These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin.
    Author: Rybak SM, Auld DS, St Clair DK, Yao QZ, Fett JW.
    Journal: Biochem Biophys Res Commun; 1989 Jul 14; 162(1):535-43. PubMed ID: 2473749.
    Abstract:
    Synthetic peptides corresponding to the C-terminal region of angiogenin (Ang) inhibit the enzymatic and biological activities of the molecule while peptides from the N-terminal region do not affect either activity. The peptide Ang(108-121) transiently abolishes the inhibition of cell-free protein synthesis caused by angiogenin coincidentally with its cleavage of reticulocyte RNA. Several C-terminal peptides also inhibit nuclease activity of angiogenin when tRNA is the substrate. Furthermore, peptide Ang(108-123) significantly decreases neovascularization elicited by angiogenin in the chick chorioallantoic membrane assay.
    [Abstract] [Full Text] [Related] [New Search]